2-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine → 1-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-methylurea

HRID 404517

反応式

HRID 404517 の反応式
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:5]=[C:4]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:3]=1.[CH3:20][NH:21][C:22]([NH:24][C:25]1[CH:30]=[CH:29][C:28](B2OC(C)(C)C(C)(C)O2)=[CH:27][CH:26]=1)=[O:23]>>[N:14]1([C:4]2[N:5]=[C:6]([N:8]3[CH2:13][CH2:12][O:11][CH2:10][CH2:9]3)[N:7]=[C:2]([C:28]3[CH:27]=[CH:26][C:25]([NH:24][C:22]([NH:21][CH3:20])=[O:23])=[CH:30][CH:29]=3)[N:3]=2)[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

参加物

3

反応物 2

HCID 2249672-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazineHCID 177502733-Methyl-1-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea

生成物 1

HCID 453792221-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-methylurea収率 11%

実験手順

The title compound was prepared by following the procedure of example 473 step 2 using 4,4′-(6-chloro-1,3,5-triazine-2,4-diyl)dimorpholine and 1-Methyl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea. Yield 13 mg, 11% yield; HPLC: Rt=1.98 min; MS 400 [M+H].

出典と根拠

ORDレコード
ord-a37e03f0659048b596e7fa6961f04cf5
出典データセット
uspto-grants-2014_06
特許番号
US08748421B2

関連ノート

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