Cysteamine → HCID 67111967、化合物
反応式
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][C:11](Cl)=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[NH2:15][CH2:16][CH2:17][SH:18]>CCO>[NH2:15][CH2:16][CH2:17][S:18][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][C:11]([S:18][CH2:17][CH2:16][NH2:15])=[CH:12][CH:13]=2)=[CH:4][CH:3]=1参加物
4
実験手順
The title compound was prepared as described by Constable et al.13 The same reaction was repeated using 6,6′-dichloro-3,3′-bipyridine (0.154 g, 0.684 mmol) in EtOH (150 mL) under reflux for 24 h to give a yellow oil. The crude product showed the presence of cysteamine (1H n.m.r.) and washing with water gave a clean product (1.3 g, 75%). Mass spectrum (ESI): m/z 153.9 [½ (M+2H)2+]; 307.2 (M+H)+. 1H n.m.r. (300 MHz, CDCl3): δ 1.5 (bs, 4H); 3.02 (t, J 6.4 Hz, 4H); 3.32 (t, J 6.4 Hz, 4H); 7.26 (dd, J 8.4, 0.6 Hz, 2H); 7.63 (dd, J 8.4, 2.4 Hz, 2H); 8.60 (d, J 2.4 Hz, 2H). 13C n.m.r. (75 MHz, CDCl3): δ 34.4; 42.1; 122.8; 129.4; 134.3; 147.7; 156.1. Spectra were consistent with literature data13.