Water → 1-(3-Chloropyridin-2-yl)piperidin-4-ol
反応式
Cl[C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][N:3]=1.O[CH:10]1[CH2:15][NH:14][CH2:13][CH2:12][CH2:11]1.[OH2:16]>CS(C)=O>[Cl:8][C:7]1[C:2]([N:14]2[CH2:13][CH2:12][CH:11]([OH:16])[CH2:10][CH2:15]2)=[N:3][CH:4]=[CH:5][CH:6]=1参加物
5
実験手順
2,3-dichloropyridine (10 g, 68 mmol) and 5-hydroxyl piperidine (compound 19) (26 g, 272 mmol) in DMSO was heated at 120° C. and stirred overnight. After the reaction was completed, three times of water was added into the reaction solution. The reaction mixture was extracted by ethyl acetate. The organic layer was evaporated to give a crude product, which was purified using column chromatography to give the product. (17 g, 93%)
後処理
- extractionThe reaction mixture was extracted by ethyl acetate
- customThe organic layer was evaporated
出典と根拠
- ORDレコード
- ord-f815850a6cf4438fa49e999c908cfc72
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08748610B2
反応ノート
読み込み中…