Hydrochloric Acid → HCID 44427825、化合物

関与物質

役割	名称	HCID	仕込み量
反応物	Hydrochloric Acid	HCID 313	—
反応物	Trans-4-[4-(2-methyloxyphenyl)piperazinyl]-2-buten-1-yl-amine	HCID 19917461	—
反応物	4-(2-Pyridyl)benzoic acid hydrochloride	HCID 68499643	—
生成物	HCID 44427825	HCID 44427825	65%

反応手順

Prepared from 4-pyridin-2-yl-benzoic acid hydrochloride and 4-(4-(2-methoxyphenyl)-piperazin-1-yl)-trans-but-2-enyl amine according to the general procedure. Yield: 65%. Mp. (hydrochloride): 168-170° C. 1H NMR (400 MHz, CDCl3): δ 2.70 (s, 4H), 3.12 (s, 6H), 3.86 (s, 3H), 4.13 (m, 2H), 5.78-5.85 (m, 2H), 6.43 (m, 1H), 6.85-7.02 (m, 4H), 7.27 (s, 2H), 7.77 (s, 2H), 7.90 (d, J 7.5, 2H), 8.06 (d, J 8.1, 2H), 8.72 (d, J 3.1, 1H). 13C NMR (101 MHz, CDCl3): δ 41.0, 50.9, 53.7, 55.8, 60.7, 111.6, 118.7, 121.3, 121.4, 123.2, 123.5, 127.5, 127.9, 129.1, 130.5, 135.0, 137.4, 141.6, 142.7, 150.3, 152.7, 156.7, 167.4. Anal. (O27H30N4O2.3HCl.4H2O) C, H, N.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08748608B2
出典データセット	uspto-grants-2014_06
ORD ID	ord-3631c5a9f74d4d3bbad614af4d4c8536
出典メモ	uspto-grants-2014_06