Hydrochloric Acid → 2-Phenyl-2-(pyrrolidin-1-yl)acetic acid hydrochloride
反応式
[C:1]1([CH:7]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[C:8]([O:10]CC)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:18]>O1CCOCC1>[ClH:18].[C:1]1([CH:7]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[C:8]([OH:10])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
4
実験手順
Ethyl 2-phenyl-2-(pyrrolidin-1-yl)acetate (0.31 g, 1.33 mmol) was dissolved in dioxane (11 ml) and 37% HCl (1.09 ml, 13.3 mmol) was added dropwise. The mixture was stirred at reflux overnight. Then 37% HCl (1.09 ml, 13.3 mmol) was added again and the reaction was refluxed for additional 24 hours. The solvent was evaporated, the residue was triturated with acetonitrile (10 ml) and the suspension was filtered on a buckner funnel. The solid was recovered to obtain 2-phenyl-2-(pyrrolidin-1-yl)acetic acid hydrochloride (0.25 g, 79% yield) as a white solid.