2-(4'-Chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone → 2-(4'-Chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione

HRID 40469ノート

反応式

HRID 40469 の反応式
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]2[CH:7]=[CH:8][C:9]([CH2:20][CH3:21])=[C:10]([C:12]3[C:13](=[O:19])[CH2:14][CH2:15][C:16]=3[O:17]C)[CH:11]=2)=[CH:4][CH:3]=1>CC(C)=O.Cl.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]2[CH:7]=[CH:8][C:9]([CH2:20][CH3:21])=[C:10]([CH:12]3[C:13](=[O:19])[CH2:14][CH2:15][C:16]3=[O:17])[CH:11]=2)=[CH:22][CH:23]=1

参加物

5

反応物 1

HCID 585028162-(4'-Chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone

生成物 1

HCID 468300792-(4'-Chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione

試薬・触媒・溶媒 3

HCID 180Acetone溶媒HCID 313Hydrochloric Acid溶媒2 回HCID 962Water溶媒

実験手順

A solution of 2-(4′-chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone (200 mg, 0.61 mmol) in acetone (4 ml) and 2M aqueous hydrochloric acid (4 ml) is heated at 120° C. for 20 minutes under microwave irradiation. The reaction mixture is diluted with water (20 ml) and 2M aqueous hydrochloric acid (10 ml), and the crude product is extracted with ethyl acetate (3×15 ml). The organic extracts are combined, washed with brine (10 ml), dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated to dryness under reduced pressure to give 2-(4′-chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione.

後処理

  1. extractionthe crude product is extracted with ethyl acetate (3×15 ml)
  2. washwashed with brine (10 ml)
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. customthe filtrate is evaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-6f7641894d3b4895a473f13086f5e497
出典データセット
uspto-grants-2013_09
特許番号
US08530388B2

反応ノート

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