6-Bromo-1-chloro-isoquinoline → 6-Bromo-1,7-dichloroisoquinoline

反応式

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[CH:8]=[N+:7]([O-])[CH:6]=[CH:5]2.BrC1C=C2C(=CC=1)C([Cl:25])=NC=C2>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[C:8]([Cl:25])=[N:7][CH:6]=[CH:5]2

参加物

反応物 2

HCID 222502446-Bromo-1-chloro-isoquinoline

HCID 592262626-Bromo-7-chloro-isoquinoline 2-oxide

生成物 1

HCID 592262696-Bromo-1,7-dichloroisoquinoline

実験手順

Starting with 6-Bromo-7-chloro-isoquinoline 2-oxide (10), the desired 6-Bromo-1,7-dichloro-isoquinoline was prepared by the method, described for 6-Bromo-1-chloro-isoquinoline (5). Rt=1.85 min (Method C). Detected mass: 276.1/278.2 (M+H+).

出典と根拠

ORDレコード: ord-660c868533574e8990fc2e46687612ed
出典データセット: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08748614B2

反応ノート

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