Tert-butyl 3-aminoazetidine-1-carboxylate → 6-(Azetidin-3-ylamino)-2H-isoquinolin-1-one hydrochloride
反応式
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7](CC1C=CC(OC)=CC=1)[CH:6]=[CH:5]2.C(OC([N:29]1[CH2:32][CH:31]([NH2:33])[CH2:30]1)=O)(C)(C)C.[ClH:34].C1C2C(=CC(NC3CCNCC3)=CC=2)C=CN=1>>[ClH:34].[NH:29]1[CH2:32][CH:31]([NH:33][C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[C:8](=[O:12])[NH:7][CH:6]=[CH:5]3)[CH2:30]1参加物
4
実験手順
6-(Azetidin-3-ylamino)-2H-isoquinolin-1-one hydrochloride was prepared by Buchwald Reaction starting from 6-Bromo-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (13) and 3-Amino-azetidine-1-carboxylic acid tert-butyl ester. BOC deprotection was performed as described for Isoquinolin-6-yl-piperidin-4-yl-amine (48).
出典と根拠
- ORDレコード
- ord-59345b38e02f4c92a1e300afb27f7c6d
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08748614B2
反応ノート
読み込み中…