Acetic Anhydride → N-((1S)-1-(4-Bromophenyl)ethyl)acetamide

HRID 40496ノート

反応式

HRID 40496 の反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Br:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([NH2:17])[CH3:16])=[CH:11][CH:10]=1.C([O-])(O)=O.[Na+]>C(Cl)Cl>[Br:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([NH:17][C:5](=[O:7])[CH3:6])[CH3:16])=[CH:11][CH:10]=1

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 516892Sodium BicarbonateHCID 852999(alphaS)-4-Bromo-alpha-methylbenzenemethanamine

生成物 1

HCID 793484N-((1S)-1-(4-Bromophenyl)ethyl)acetamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

23.6 mL (250 mmol) acetic anhydride are added to 50.0 g (250 mmol) (S)-1-(4-bromophenyl)-ethylamine in 200 mL DCM while keeping the reaction temperature below 30° C. Stirring is continued for 12 h at rt. After that time, saturated NaHCO3-solution is added. The organic layer is separated, washed with water, dried over magnesium sulphate and the solvent is removed by evaporation.

後処理

  1. customthe reaction temperature below 30° C
  2. customThe organic layer is separated
  3. washwashed with water
  4. dry with materialdried over magnesium sulphate
  5. customthe solvent is removed by evaporation

出典と根拠

ORDレコード
ord-f96979fe72f74084b61a860b344e7a4f
出典データセット
uspto-grants-2013_09
特許番号
US08530461B2

反応ノート

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