反応式
C(O)C[C:3]1[CH:11]=[CH:10][C:8](O)=[C:5]([O:6][CH3:7])[CH:4]=1.[C:13](=[O:16])([O-])[O-].[K+].[K+].[CH3:19]S(Cl)(=O)=O.[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH2:34][C:35]#[N:36])[CH:29]=[CH:30][C:31]=1[O:32][CH3:33].I[CH:38]([CH3:40])[CH3:39].[CH2:41]([N:43]([CH2:46][CH3:47])[CH2:44][CH3:45])C>>[CH3:39][CH:38]([C:34]([C:28]1[CH:29]=[CH:30][C:31]([O:32][CH3:33])=[C:26]([O:25][CH3:24])[CH:27]=1)([C:35]#[N:36])[CH2:19][CH2:45][CH2:44][N:43]([CH2:46][CH2:47][C:10]1[CH:11]=[CH:3][C:4]([O:16][CH3:13])=[C:5]([O:6][CH3:7])[CH:8]=1)[CH3:41])[CH3:40]参加物
実験手順
In carrying out this synthesis, the following materials were used. Homovanillyl alcohol, Aldrich, 99%, Cat. No. 148830-10G, Batch No. 19516EO; potassium carbonate, Aldrich, 99%; triethylamine, Aldrich, 99.5%, Cat. No. 471283-500 mL, Batch No. 04623HD; methanesulfonyl chloride, Aldrich, 99.5%, Cat. No. 471259-500 mL, Batch No. 13209KC; 3.4-dimethoxyphenylacetonitrile, Aldrich, Cat. No. 126349-100G, Batch No. 08011BD; 2-iodopropane, Aldrich, 99%, Cat. No. 148938-100G, Batch #, 03604DD; diisopropylamine, redistilled, Aldrich, 99.95%, Cat. No. 386464-100 mL, Batch #00944TD; butyllithium, 1.6 M solution in hexanes, Aldrich, Cat. No. 186171-100 mL, Batch #20709PD; 3-bromo-1-propanol, Aldrich, 97%, Cat. No. 167169-25G, Batch No. 0901DE; dichloromethane, Aldrich, Cat. No. 270997-2L, Batch #: 004341CD; sodium triacetoxyborohydride, Aldrich, 95%, Cat. No. 316393-25G, Batch No. 07920LD; N,N-diisopropylethylamine, Aldrich, Cat. No. 387649-100 mL, Batch No. 06448PC; N-methylhomoveratrylamine, Aldrich, Cat. No. 334774, Batch No. 10421EO.
後処理
- customthis synthesis
- distillationdiisopropylamine, redistilled
出典と根拠
- ORDレコード
- ord-a00d292325c7405c840043794b2e329e
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08748648B2
関連ノート
読み込み中…