4-Oxazolecarboxylic acid, 2-(acetylamino)-, ethyl ester → 2-Acetamidooxazole-4-carboxylic acid
反応式
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12](=[O:14])[CH3:13])[O:9][CH:10]=1)=[O:5])C>C(O)C>[C:12]([NH:11][C:8]1[O:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=1)(=[O:14])[CH3:13]参加物
3
実験手順
1.3 g (6.60 mmol) 2-Acetylamino-oxazole-4-carboxylic acid ethyl ester is added to 33 mL ethanol. 0.55 g (13.2 mmol) LiOH monohydrate is added and the mixture is stirred for 12 h at rt. The mixture is concentrated in vacuo, acidified by means of aq. HCl solution and the precipitate is collected and washed with cold water to yield the desired product.
後処理
- concentrationThe mixture is concentrated in vacuo
- customthe precipitate is collected
- washwashed with cold water
出典と根拠
- ORDレコード
- ord-e363e39bc3a3467ba41fe9eef87d8f31
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08530461B2
反応ノート
読み込み中…