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Acetic Acid → Ethyl 3-(5-(4-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)amino)methyl)phenyl)picolinamido)propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 4-Amino-4'-chlorodiphenyl | HCID 8675 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | Ethyl 3-(5-(4-chloro-2-formylphenyl)picolinamido)propanoate | HCID 86674245 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Ethyl 3-(5-(4-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)amino)methyl)phenyl)picolinamido)propanoate | HCID 71059961 | — |
反応手順
Solid NaBH(OAc)3 (110 mg, 0.52 mmol) was added to a THF solution (1.7 mL) of ethyl 3-(5-(4-chloro-2-formylphenyl)picolinamido)propanoate (125 mg, 0.35 mmol), 4′-chloro-[1,1′-biphenyl]-4-amine (106 mg, 0.52 mmol), and AcOH (0.02 mL, 0.35 mmol) and the resulting mixture was stirred at room temperature. After 16 h the resulting mixture diluted with EtOAc washed with water and brine, dried (Na2SO4), dry-packed onto silica gel and purified via column chromatography to yield the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08748624B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-722cbe1656444b1fa233e3a0f5126017 |
| 出典メモ | uspto-grants-2014_06 |