Acetic Acid → Ethyl 3-(5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)amino)methyl)phenyl)picolinamido)propanoate

関与物質

役割	名称	HCID	仕込み量
反応物	Acetic Acid	HCID 176	—
反応物	4-Amino-4'-chlorodiphenyl	HCID 8675	—
反応物	Sodium triacetoxyborohydride	HCID 5049666	—
反応物	Ethyl 3-(5-(5-chloro-2-formylphenyl)picolinamido)propanoate	HCID 86674246	—
溶媒	1,2-Dichloroethane	HCID 11	—
溶媒	Ethyl Acetate	HCID 8857	—
生成物	Ethyl 3-(5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)amino)methyl)phenyl)picolinamido)propanoate	HCID 71059834	—

反応手順

Solid NaBH(OAc)3 (388 mg, 1.83 mmol) was added to a DCE solution (2 mL) of ethyl 3-(5-(5-chloro-2-formylphenyl)picolinamido)propanoate (330 mg, 0.92 mmol), 4′-chloro-[1,1′-biphenyl]-4-amine (186 mg, 0.92 mmol), and AcOH (0.21 mL, 3.66 mmol) and the resulting mixture was stirred at room temperature. After 16 h the resulting mixture diluted with EtOAc washed with water and brine, dried (Na2SO4), dry-packed onto silica gel and purified via column chromatography to yield the title compound.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08748624B2
出典データセット	uspto-grants-2014_06
ORD ID	ord-d762f74b1e1445fca55096b2d0257abb
出典メモ	uspto-grants-2014_06