1-Bromo-3-chloro-2-iodo-5-(trifluoromethyl)benzene → HCID 71060016、化合物
反応式
[Br:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1I.[C:14]([Cu])#[N:15]>CN(C=O)C.C(Cl)Cl>[Br:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[C:14]#[N:15]参加物
5
反応条件
- 温度
- 100 °C
実験手順
1-bromo-3-chloro-2-iodo-5-(trifluoromethyl)benzene (8.0 g, 20.6 mmol) and CuCN (1.9 g, 20.6 mmol) were dissolved in DMF (20 mL) and heated 100° C. After 2 h the temperature was increased to 110° C. After 3 h the reaction was cooled to room temperature, diluted with DCM, filtered, concentrated, and purified via column chromatography to yield the title compound.
後処理
- temperatureAfter 2 h the temperature was increased to 110° C
- temperatureAfter 3 h the reaction was cooled to room temperature
- filtrationfiltered
- concentrationconcentrated
- custompurified via column chromatography
出典と根拠
- ORDレコード
- ord-8519e4132f5d4c42ad1b5d85a7a51385
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08748624B2
反応ノート
読み込み中…