Boron tribromide → HCID 86674268、化合物
反応式
B(Br)(Br)Br.[Cl:5][C:6]1[C:7]([C:16]([F:19])([F:18])[F:17])=[CH:8][C:9]([O:14]C)=[C:10]([CH:13]=1)[CH:11]=[O:12]>C(Cl)Cl>[Cl:5][C:6]1[C:7]([C:16]([F:17])([F:18])[F:19])=[CH:8][C:9]([OH:14])=[C:10]([CH:13]=1)[CH:11]=[O:12]参加物
4
反応条件
- 温度
- 50 °C
実験手順
A 1M DCM solution of BBr3 (24.0 mL, 24.0 mmol) was added to neat 5-chloro-2-methoxy-4-(trifluoromethyl)benzaldehyde (3.4 g, 14.4 mmol) and the resulting mixture was heated to 50° C. After 1 h the resulting mixture was diluted with DCM and ice and the layers were separated. The aqueous phase was added was extracted with DCM and the combined organics were dried (Na2SO4), concentrated and purified via column chromatography to yield the title compound.
後処理
- customthe layers were separated
- additionThe aqueous phase was added
- extractionwas extracted with DCM
- dry with materialthe combined organics were dried (Na2SO4)
- concentrationconcentrated
- custompurified via column chromatography
出典と根拠
- ORDレコード
- ord-e2f177fa195a4d14adf31e690d64a582
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08748624B2
反応ノート
読み込み中…