N-((1S)-1-(4-Bromophenyl)ethyl)acetamide → (S)-N-(1-{4-[3-(4-Benzyloxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

HRID 40520ノート

反応式

HRID 40520 の反応式
[CH2:1]([O:8][C:9]1[CH:19]=[CH:18][C:12]([O:13][CH:14]2[CH2:17][NH:16][CH2:15]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:21]1[CH:26]=[CH:25][C:24]([C@@H:27]([NH:29][C:30](=[O:32])[CH3:31])[CH3:28])=[CH:23][CH:22]=1>>[CH2:1]([O:8][C:9]1[CH:19]=[CH:18][C:12]([O:13][CH:14]2[CH2:17][N:16]([C:21]3[CH:26]=[CH:25][C:24]([C@@H:27]([NH:29][C:30](=[O:32])[CH3:31])[CH3:28])=[CH:23][CH:22]=3)[CH2:15]2)=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 793484N-((1S)-1-(4-Bromophenyl)ethyl)acetamideHCID 534095563-[4-(Benzyloxy)phenoxy]azetidine

生成物 1

HCID 86689007(S)-N-(1-{4-[3-(4-Benzyloxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

反応条件

温度
30 °C

実験手順

Example 8.5 is prepared analogously to 8.1. 3-(4-Benzyloxy-phenoxy)-azetidine and (S)—N-[1-(4-bromo-phenyl)-ethyl]-acetamide (I.1) are used as starting materials. Reaction conditions are stirring for 2 days at 30° C.

後処理

  1. customExample 8.5 is prepared analogously to 8.1
  2. customReaction conditions

出典と根拠

ORDレコード
ord-28757e03b49a4eccbe90e35c5a61a548
出典データセット
uspto-grants-2013_09
特許番号
US08530461B2

反応ノート

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