関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Lithium diisopropylamide | HCID 2724682 | — |
| 反応物 | 1-Chloro-3-(methoxymethoxy)-5-(trifluoromethyl)benzene | HCID 86674286 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Chloro-6-(methoxymethoxy)-4-(trifluoromethyl)benzaldehyde | HCID 86674287 | — |
反応手順
A 1.6M LDA solution (12.6 mL, 20.1 mmol) was added to a −78° C. THF solution (50 mL) of 1-chloro-3-(methoxymethoxy)-5-(trifluoromethyl)benzene (from above). After 30 min neat DMF (3.9 mL, 50.0 mmol) was added, and the resulting solution was allowed to warm to 0° C. gradually, quenched with NH4Cl solution, and extracted with diethyl ether. The combined extracts were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08748624B2 |
|---|
| 出典データセット | uspto-grants-2014_06 |
|---|
| ORD ID | ord-18cdfcacb0de4a1bac2fe48d611cf668 |
|---|
| 出典メモ | uspto-grants-2014_06 |
|---|
