化工社化工社 化学情報印刷レポート · 研究参考用
4-Isopropoxyaniline → 5-Fluoropyrimidine-2,4-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Isopropoxyaniline | HCID 82112 | — |
| 反応物 | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| 反応物 | R-112 | HCID 9904854 | — |
| 生成物 | 5-Fluoropyrimidine-2,4-diamine | HCID 255608 | — |
反応手順
In a manner similar to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 4-isopropoxyaniline were reacted to yield N2,N4-bis(4-isopropoxy)phenyl)-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CDCl3): δ 7.89 (bs, 1H), 7.47 (d, 2H, J=8.7 Hz), 7.38 (d, 2H, J=9.0 Hz), 6.87 (d, 2H, J=9.0 Hz), 6.83 (d, 2H, J=8.7 Hz); LCMS: ret. time: 27.51 min.; purity: 98%; MS (m/e): 397 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08748597B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-785436e8cb7047c2bb1b202c52e0b1a8 |
| 出典メモ | uspto-grants-2014_06 |