Hydrochloric Acid → Thiomorpholine, 4-(4-piperidinyl)-, 1,1-dioxide

HRID 40546ノート

反応式

HRID 40546 の反応式
[O:1]=[S:2]1(=[O:17])[CH2:7][CH2:6][N:5]([CH:8]2[CH2:13][CH2:12][N:11](C(O)=O)[CH2:10][CH2:9]2)[CH2:4][CH2:3]1.Cl>ClCCl.O1CCOCC1>[NH:11]1[CH2:10][CH2:9][CH:8]([N:5]2[CH2:4][CH2:3][S:2](=[O:1])(=[O:17])[CH2:7][CH2:6]2)[CH2:13][CH2:12]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 676080954-(1,1-Dioxo-1lambda6-thiomorpholin-4-yl)-piperidine-1-carboxylic acid

生成物 1

HCID 43532698Thiomorpholine, 4-(4-piperidinyl)-, 1,1-dioxide

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

0.786 g of tert-butyl ester of 4-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-piperidine-1-carboxylic acid is put in 5 ml of dichloromethane. 12.3 ml of 4M hydrochloric acid in dioxane is added at room temperature. The solution is stirred for 18 h and evaporated to dryness. The product thus obtained is returned to the basic state by means of tetraalkylammonium carbonate resin at a rate of 2 g per mmol. 0.555 g of 4-piperidin-4-yl-thiomorpholine 1,1-dioxide is obtained.

後処理

  1. customevaporated to dryness
  2. customThe product thus obtained

出典と根拠

ORDレコード
ord-9a6d4185f94349fdb3f966984385e18c
出典データセット
uspto-grants-2013_09
特許番号
US08530473B2

反応ノート

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