化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → Hydroxyamfetamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 4-Hydroxyphenylacetone | HCID 7019274 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Hydroxyamfetamine | HCID 3651 | — |
反応手順
A mixture of 7.00 g (46.6 mmol) 4-hydroxyphenylacetone and 200 mL 7N ammonia in MeOH is charged with 0.70 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (50 psi) at r.t. over night. After complete reaction, the mixture is filtrated, the solvent is removed in vacuo and the crude product is purified by HPLC (MeOH/H2O/NH3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08530460B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-cb14c09e723444f6967e7938a6ec22f0 |
| 出典メモ | uspto-grants-2013_09 |