Ammonia → Hydroxyamfetamine

HRID 40556

反応式

HRID 40556 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=O)[CH3:10])=[CH:4][CH:3]=1.[NH3:12].[H][H]>CO.[Ni]>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH2:12])[CH3:10])=[CH:4][CH:3]=1

参加物

6

反応物 3

HCID 222AmmoniaHCID 70192744-HydroxyphenylacetoneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 3651Hydroxyamfetamine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A mixture of 7.00 g (46.6 mmol) 4-hydroxyphenylacetone and 200 mL 7N ammonia in MeOH is charged with 0.70 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (50 psi) at r.t. over night. After complete reaction, the mixture is filtrated, the solvent is removed in vacuo and the crude product is purified by HPLC (MeOH/H2O/NH3).

後処理

  1. customAfter complete reaction
  2. filtrationthe mixture is filtrated
  3. customthe solvent is removed in vacuo
  4. customthe crude product is purified by HPLC (MeOH/H2O/NH3)

出典と根拠

ORDレコード
ord-cb14c09e723444f6967e7938a6ec22f0
出典データセット
uspto-grants-2013_09
特許番号
US08530460B2

関連ノート

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