Dimethylformamide → 1-Bromo-4-(cyclopropylmethoxy)benzene
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[CH2:10][CH:11]1[CH2:13][CH2:12]1.C([O-])([O-])=O.[K+].[K+].CN(C=O)C>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH:11]2[CH2:13][CH2:12]2)=[CH:4][CH:3]=1参加物
6
反応条件
- 温度
- 80 °C
実験手順
5.0 g (28.9 mmol) 4-bromophenol, 3.93 g (43.4 mmol) (chloromethyl)cyclopropane and 7.99 g (57.8 mmol) K2CO3 are added to 10 mL DMF and stirred at 80° C. over night. Afterwards the reaction mixture is diluted with water and extracted with DCM. The organic layer is dried with MgSO4 and the solvent is removed in vacuo.
後処理
- extractionextracted with DCM
- dry with materialThe organic layer is dried with MgSO4
- customthe solvent is removed in vacuo
出典と根拠
- ORDレコード
- ord-2949511e5a7443a78404720baec74d54
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08530460B2
反応ノート
読み込み中…