関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Cyclobutylamine | HCID 75645 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 5-Bromo-2-chloropyrimidine | HCID 606665 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 5-bromo-N-cyclobutylpyrimidin-2-amine | HCID 45158687 | — |
反応手順
In a sealed tube 2.00 g (10.3 mmol) 5-bromo-2-chloropyrimidine, 1.15 mL (13.4 mmol) cyclobutylamin and 2.70 mL (15.5 mmol) DIPEA are added to 12 mL ACN. The reaction mixture is stirred at 50° C. over night, then diluted with EtOAc and washed with water (2×). The org. phase is dried with MgSO4 and the solvent is removed in vacuo.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08530460B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-2a3a2743c1e9484fb35ba6c301538793 |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
