Benzoic Acid → 5-Chloro-2-phenyloxazolo[5,4-d]pyrimidine

HRID 40565ノート

反応式

HRID 40565 の反応式
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:10][C:11]1[N:16]=[CH:15][C:14]([NH2:17])=[C:13](Cl)[N:12]=1>O=P(Cl)(Cl)Cl>[Cl:10][C:11]1[N:12]=[CH:13][C:14]2[N:17]=[C:1]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[O:9][C:15]=2[N:16]=1

参加物

4

反応物 2

HCID 243Benzoic AcidHCID 2577975-Amino-2,4-dichloropyrimidine

生成物 1

HCID 149130905-Chloro-2-phenyloxazolo[5,4-d]pyrimidine

試薬・触媒・溶媒 1

HCID 24813Phosphorus oxychloride溶媒

実験手順

7.82 g (64.0 mmol) benzoic acid and 20 mL POCl3 are stirred together at 100° C. for 30 min. Within 45 min 7.00 g (42.7 mmol) 2,6-dichloro-5-aminopyrimidine are added by several portions. The reaction mixture is stirred for additional 2 h at the same temperatur. After that the mixture is carefully added to an ice cold aq. NaOH solution. The resulting precipitate is filtered, washed with water and dried.

後処理

  1. filtrationThe resulting precipitate is filtered
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-0a7236edd7b34ad4bd3310e7c1c86518
出典データセット
uspto-grants-2013_09
特許番号
US08530460B2

反応ノート

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