tert-Butylsulfinamide, (R)-(+)- → HCID 178455587、化合物

反応式

[F:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[F:11])=O.[C:12]([S@:16]([NH2:18])=[O:17])([CH3:15])([CH3:14])[CH3:13]>>[F:1][CH2:2]/[C:3](=[N:18]\[S@@:16]([C:12]([CH3:15])([CH3:14])[CH3:13])=[O:17])/[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[F:11]

参加物

反応物 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-

HCID 219644912-Fluoro-1-(2-fluorophenyl)ethan-1-one

生成物 1

HCID 178455587HCID 178455587、化合物収率 52%

実験手順

In a manner analogous to that described for the preparation of sulfinyl imine A2.1 the reaction of 2-fluoro-1-(2-fluoro-phenyl)-ethanone with (R)-tert-butylsulfinamide yielded the (R)-2-methyl-propane-2-sulfinic acid [2-fluoro-1-(2-fluoro-phenyl)-eth-(Z)-ylidene]-amide (52% of theory) as an orange oil. MS (ISP): m/z=260.2 [M+H]+.

出典と根拠

ORDレコード: ord-41e92b303e164a5fa1b8796be8798c2c
出典データセット: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08754075B2

反応ノート

読み込み中…

参加物