戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 405746作成日：2026年10月26日

1,5-dimethyl-1H-pyrazole-3-carboxylic acid → 1,5-Dimethyl-1H-pyrazole-3-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

https://huagongshe.com/reaction/405746

反応式

関与物質

役割名称HCID仕込み量
反応物1,5-dimethyl-1H-pyrazole-3-carboxylic acidHCID 587757—
反応物(4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 86672004—
生成物1,5-Dimethyl-1H-pyrazole-3-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amideHCID 66559184—

反応手順

The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 1,5-dimethyl-1H-pyrazole-3-carboxylic acid (CAS 5744-59-2) following procedure I yielded the title compound as a white solid. MS (ISP): m/z=364.3 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08754075B2
出典データセットuspto-grants-2014_06
ORD IDord-7046c3fe892c453392dc866ee9f9e6a4
出典メモuspto-grants-2014_06