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HRID 405761作成日：2026年10月27日

4-Chloro-1-(2,2-difluoroethyl)-1H-pyrazole-3-carboxylic acid → 4-Chloro-1-(2,2-difluoro-ethyl)-1H-pyrazole-3-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4,5-dimethyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]amide

https://huagongshe.com/reaction/405761

反応式

関与物質

役割名称HCID仕込み量
反応物4-Chloro-1-(2,2-difluoroethyl)-1H-pyrazole-3-carboxylic acidHCID 19622801—
反応物(4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4,5-dimethyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 86672006—
生成物4-Chloro-1-(2,2-difluoro-ethyl)-1H-pyrazole-3-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4,5-dimethyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]amideHCID 66559187—

反応手順

The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4,5-dimethyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (A8.3) and 4-chloro-1-(2,2-difluoro-ethyl)-1H-pyrazole-3-carboxylic acid (CAS 1006486-42-5) following procedure I yielded the title compound as a white solid. MS (ISP): m/z=448.2 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08754075B2
出典データセットuspto-grants-2014_06
ORD IDord-e0181c15b3f84f0ab7e578579da82510
出典メモuspto-grants-2014_06