4-Benzylpiperidine → 4-benzyl-N-(4-methylphenyl)piperidine-1-carboxamide

反応式

[CH2:1]([CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:14]1([C:20]2[CH:25]=[CH:24][C:23]([N:26]=[C:27]=[O:28])=[CH:22][CH:21]=2)C=CC=CC=1>>[C:20]1([CH3:14])[CH:25]=[CH:24][C:23]([NH:26][C:27]([N:11]2[CH2:12][CH2:13][CH:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH2:9][CH2:10]2)=[O:28])=[CH:22][CH:21]=1

参加物

反応物 2

HCID 317384-Benzylpiperidine

HCID 36123194-Biphenylyl isocyanate

生成物 1

HCID 18368144-benzyl-N-(4-methylphenyl)piperidine-1-carboxamide

実験手順

The title compound was prepared from 4-benzylpiperidine and 4-phenylphenyl isocyanate. 1H NMR (400 MHz, CDCl3): 7.31-7.12 (m, 7H), 7.07 (d, J=8.0 Hz, 2H), 6.32 (s, 1H), 4.06-4.00 (m, 2H), 2.79 (td, J=13, 2.5 Hz, 2H), 2.56 (d, J=6.8 Hz, 2H), 2.28 (s, 3H), 1.79-0.165 (m, 3H), 1.30-1.18 (m, 2H).

出典と根拠

ORDレコード: ord-93f9d792d1824ab19068913b7236828e
出典データセット: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08530476B2

反応ノート

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