2-Amino-5-chlorophenol → HCID 58117890、化合物

反応式

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].[N:10]1(C(OC(C)(C)C)=O)[CH2:15][CH2:14][CH:13]([C:16]([O-])=O)[CH2:12][CH2:11]1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]2[N:1]=[C:16]([CH:13]3[CH2:14][CH2:15][NH:10][CH2:11][CH2:12]3)[O:9][C:3]=2[CH:4]=1

参加物

反応物 2

HCID 915912-Amino-5-chlorophenol

HCID 6921829HCID 6921829、化合物

生成物 1

HCID 58117890HCID 58117890、化合物収率 103.1%

実験手順

500 mg 2-amino-5-chlorophenol and 800 mg mono-tert-butyl piperidine-1,4-dicarboxylate are heated to 200° C. in 4 ml polyphosphoric acid for 4 h. After cooling the reaction mixture is combined with ice water and stirred for 30 min. The precipitate is suction filtered, washed with water and dried. 850 mg product are obtained as the phosphate.

後処理

temperatureAfter cooling the reaction mixture
filtrationfiltered
washwashed with water
customdried

出典と根拠

ORDレコード: ord-bfc808555a5742d8a71cbeab465bfb8f
出典データセット: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08754073B2

反応ノート

読み込み中…

参加物