化工社化工社 化学情報印刷レポート · 研究参考用
n-Methyl-3-nitropyridin-4-amine → 4-N-methylpyridine-3,4-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | n-Methyl-3-nitropyridin-4-amine | HCID 556016 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-N-methylpyridine-3,4-diamine | HCID 910412 | 83.8% |
反応手順
2.3 g methyl-(3-nitropyridin-4-yl)-amine are hydrogenated in 50 ml of methanol for and with 0.8 g Raney nickel for 2.5 h at 50° C. and 50 psi hydrogen pressure. The catalyst is filtered off and the filtrate is evaporated to dryness. The product is purified by chromatography (Alox, dichloromethane/methanol from 99/1 to 19/1). 1.55 g product are obtained as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08754073B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-15a1784810ef4e29b7c08e8f34ae74ca |
| 出典メモ | uspto-grants-2014_06 |