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Hydroxyamine hydrochloride → 4,6-Dichloro-5-pyrimidinecarbaldehyde oxime
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | 4,6-Dichloro-5-pyrimidinecarbaldehyde | HCID 819691 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4,6-Dichloro-5-pyrimidinecarbaldehyde oxime | HCID 76016516 | — |
反応手順
A mixture of 4,6-dichloropyrimidine-5-carbaldehyde (8.00 g, 44.8 mmol), NaOAc (3.7 g, 1.0 eq) and NH2OH.HCl (3.1 g, 1.0 eq) in EtOH (320 mL) was stirred at rt for 2 h. The reaction mixture was filtered, concd and purified by column chromatography on silica gel (dry loading, first DCM then DCM/EtOAc, 1/9) to give 4,6-dichloropyrimidine-5-carbaldehyde oxime as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08754089B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-afbae19d534f4d49a5b77e55dbfc9687 |
| 出典メモ | uspto-grants-2014_06 |