phenyl N-(1,3-thiazol-2-yl)carbamate → 4-Quinolin-3-ylmethyl-piperazine-1-carboxylic acid thiazol-2-ylamide

HRID 40608

反応式

HRID 40608 の反応式
C1(O[C:8](=[O:15])[NH:9][C:10]2[S:11][CH:12]=[CH:13][N:14]=2)C=CC=CC=1.[N:16]1([CH2:22][C:23]2[CH:24]=[N:25][C:26]3[C:31]([CH:32]=2)=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[S:11]1[CH:12]=[CH:13][N:14]=[C:10]1[NH:9][C:8]([N:19]1[CH2:20][CH2:21][N:16]([CH2:22][C:23]2[CH:24]=[N:25][C:26]3[C:31]([CH:32]=2)=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:17][CH2:18]1)=[O:15]

参加物

3

反応物 2

HCID 651148phenyl N-(1,3-thiazol-2-yl)carbamateHCID 578808813-[(Piperazin-1-yl)methyl]quinoline

生成物 1

HCID 578808824-Quinolin-3-ylmethyl-piperazine-1-carboxylic acid thiazol-2-ylamide

実験手順

The title compound was prepared from thiazol-2-yl-carbamic acid phenyl ester and 3-piperazin-1-ylmethyl-quinoline in analogy with Example 142. 1H NMR (400 MHz, CDCl3): 9.03 (d, J=2.0 Hz, 1H), 8.24-8.20 (m, 2H), 7.94 (d, J=8.1 Hz, 1H), 7.86-7.81 (m, 1H), 7.70-7.66 (m, 1H), 7.43 (d, J=3.3 Hz, 1H), 6.98 (d, J=3.5 Hz, 1H), 3.87 (s, 2H), 3.73-3.69 (m, 4H), 2.68 (bs, 4H).

出典と根拠

ORDレコード
ord-5d137eef317d4db6994ddb23858406ff
出典データセット
uspto-grants-2013_09
特許番号
US08530476B2

関連ノート

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