Water → Ethyl 4-(2-(2,3-dip-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)ethylamino)-4-oxobutanoate

HRID 406220ノート

反応式

HRID 406220 の反応式
[C:1]1([CH3:27])[CH:6]=[CH:5][C:4]([C:7]2[N:8]=[C:9]3[CH2:23][CH2:22][CH2:21][N:20]([CH2:24][CH2:25][NH2:26])[C:10]3=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)=[CH:3][CH:2]=1.C(N([CH2:33][CH3:34])CC)C.C([CH:37]([CH2:41][C:42](Cl)=[O:43])[C:38](Cl)=[O:39])C.[OH2:45]>C(OCC)(=O)C>[C:1]1([CH3:27])[CH:2]=[CH:3][C:4]([C:7]2[N:8]=[C:9]3[CH2:23][CH2:22][CH2:21][N:20]([CH2:24][CH2:25][NH:26][C:42](=[O:43])[CH2:41][CH2:37][C:38]([O:39][CH2:33][CH3:34])=[O:45])[C:10]3=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)=[CH:5][CH:6]=1

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 218646082-Ethylbutanedioyl dichlorideHCID 666659362-(2,3-Dip-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)ethanamine

生成物 1

HCID 66666378Ethyl 4-(2-(2,3-dip-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)ethylamino)-4-oxobutanoate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A mixture comprising 2-(2,3-dip-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)ethanamine (step 2) (108 mg, 0.301 mmol) in ethyl acetate (5 ml) and triethylamine (0.084 ml, 0.603 mmol) at RT was treated dropwise with ethyl succinyl chloride (74.4 mg, 0.452 mmol) and the resulting suspension was stirred at RT for 30 minutes. The mixture was poured into water and extracted with ethyl acetate. The organic layer was separated, dried over and concentrated in vacuo to afford the title compound;

後処理

  1. extractionextracted with ethyl acetate
  2. customThe organic layer was separated
  3. customdried over and
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-4182bbc5ebd74ede9648726c6fd7a795
出典データセット
uspto-grants-2014_06
特許番号
US08754085B2

反応ノート

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