Diisopropylethylamine → (S)-1-(6-Methyl-pyridin-3-yloxy)-3-(-(Z)-(1S,6S)-9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-2-ol

関与物質

役割	名称	HCID	仕込み量
反応物	Diisopropylethylamine	HCID 81531	—
反応物	Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene	HCID 59686818	—
反応物	(S)-2-Methyl-5-oxiranylmethoxy-pyridine	HCID 59686824	—
溶媒	Ethanol	HCID 702	—
生成物	(S)-1-(6-Methyl-pyridin-3-yloxy)-3-(-(Z)-(1S,6S)-9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-2-ol	HCID 59686804	—

反応条件

温度	95 °C

反応手順

(S)-2-Methyl-5-oxiranylmethoxy-pyridine (13 mg, 0.077 mmol) and Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene (20 mg, 0.189 mmol) were placed in a μW tube with ethanol (3 ml), DIPEA (15 μL, 0.086 mmol) and heated to 95° C. for 900 sec. The solvent was removed and the residue was purified via silica chromatography (30% Ethyl acetate/heptane) to yield the title compound as a residue.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08530475B2
出典データセット	uspto-grants-2013_09
ORD ID	ord-5d40740e23a44ef7bd32cf080e50788b
出典メモ	uspto-grants-2013_09