Benzoic acid, 3-nitro-4-(1-piperidinyl)-, methyl ester → methyl 3-amino-4-piperidin-1-ylbenzoate

HRID 406392ノート

反応式

HRID 406392 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:7]([O:9][CH3:10])=[O:8])([O-])=O>CO.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:7]([O:9][CH3:10])=[O:8]

参加物

4

反応物 1

HCID 2878938Benzoic acid, 3-nitro-4-(1-piperidinyl)-, methyl ester

生成物 1

HCID 1250441methyl 3-amino-4-piperidin-1-ylbenzoate収率 85.2%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

Using 10% palladium carbon cartridge, a solution of methyl 3-nitro-4-(piperidin-1-yl)benzoate (3.07 g) in methanol (50 ml) was pumped through the H-Cube™ reactor (ThalesNano Inc.). After all the reaction mixture had passed through the H-Cube™ reactor, the reaction mixture was concentrated under reduced pressure. The residue was purified by NH-silica gel column chromatography to obtain a title compound (2.32 g).

後処理

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customThe residue was purified by NH-silica gel column chromatography

出典と根拠

ORDレコード
ord-499299740561403c805c413cc3cb0f8b
出典データセット
uspto-grants-2014_06
特許番号
US08754100B2

反応ノート

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