化工社化工社 化学情報印刷レポート · 研究参考用
HRID 40640作成日：2026年10月25日
Ethyl Acetate → 1-(1H-Indol-4-yloxy)-3-(9-naphthalen-2-ylmethyl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-2-ol
https://huagongshe.com/reaction/40640
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | 4-(oxiran-2-ylmethoxy)-1H-indole | HCID 605015 | — |
| 反応物 | Z-(1S,6S)-7-naphthalen-2-ylmethyl-7,9-diaza-bicyclo[4.2.2]dec-3-ene | HCID 59686832 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-(1H-Indol-4-yloxy)-3-(9-naphthalen-2-ylmethyl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-2-ol | HCID 69234947 | — |
反応手順
Z-(1S,6S)-7-naphthalen-2-ylmethyl-7,9-diaza-bicyclo[4.2.2]dec-3-ene (30 mg, 0.064 mmol), ethyl acetate (0.5 mL) and 4-oxiranylmethoxy-1H-indole (50 mg, 0.26 mmol) were placed in a μW tube with ethanol (3 ml) and heated to 95° C. for 900 sec. The solvent was evaporated to yield a crude oil, which was purified via flash chromatography (15% Ethyl acetate/heptane to 100% Ethyl acetate) to yield the title compound as a residue.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08530475B2 |
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| 出典データセット | uspto-grants-2013_09 |
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| ORD ID | ord-765c01a4a9d14881ae9a0371187c4510 |
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| 出典メモ | uspto-grants-2013_09 |
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