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HRID 406456作成日：2026年10月26日

Halauxifen-methyl → Methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate

https://huagongshe.com/reaction/406456

反応式

関与物質

役割名称HCID仕込み量
反応物Halauxifen-methylHCID 16656802—
反応物Methyl 4-acetamido-3,6-dichloropyridine-2-carboxylateHCID 22677481—
生成物Methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylateHCID 67210962—

反応手順

Methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate is produced from a 4-chloro-2-fluoro-3-substituted-phenylboronic acid derivative, such as PBA. As shown in the reaction scheme below, the methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate (Compound 1) is produced by reacting PBA (Compound 2) with methyl 4-(acetylamino)-3,6-dichloropyridine-2-carboxylate (Compound 3) to produce methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate (Compound 4), which is deacetylated to produce Compound 1:

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08754110B2
出典データセットuspto-grants-2014_06
ORD IDord-cb2f188a09144ffcb0784a37bcc4f99a
出典メモuspto-grants-2014_06