化工社化工社 化学情報印刷レポート · 研究参考用
Methyl morpholine oxide → 3-Chloro-1-benzothiophene-2-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl morpholine oxide | HCID 82029 | — |
| 反応物 | (3-Chloro-1-benzothien-2-yl)methanol | HCID 821965 | — |
| 触媒 | HCID 178419074 | HCID 178419074 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Chloro-1-benzothiophene-2-carbaldehyde | HCID 818121 | 84.7% |
反応手順
A solution of alcohol 12 (4.32 g, 21.6 mmol) in 40 mL of CH2Cl2 was treated with 4A molecular sieves, NMO (3.81 g, 32.5 mmol), and TPAP (381 mg, 1.08 mmol). The reaction was stirred for 10 min. and then was evaporated to dryness. Purification by flash chromatography on silica gel (2% ethyl acetate/hexane) gave 3.52 g (18.3 mmol, 84%) of the aldehyde (13).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08754122B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-1a7ba306a4944da791246b5d6332cddc |
| 出典メモ | uspto-grants-2014_06 |