4-(Methylamino)tetrahydro-2H-pyran → HCID 57384890、化合物

HRID 407033

反応式

HRID 407033 の反応式
[F:1][C:2]([F:34])([F:33])[CH2:3][NH:4][C:5]([NH:7][C:8]1[CH:9]=[C:10]([C:14]2[N:18]3[N:19]=[CH:20][C:21]([C:23]4[CH:24]=[N:25][N:26]([CH:28]([CH3:32])[C:29]([OH:31])=O)[CH:27]=4)=[CH:22][C:17]3=[N:16][CH:15]=2)[CH:11]=[CH:12][CH:13]=1)=[O:6].[CH3:35][NH:36][CH:37]1[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1>>[CH3:35][N:36]([CH:37]1[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1)[C:29](=[O:31])[CH:28]([N:26]1[CH:27]=[C:23]([C:21]2[CH:20]=[N:19][N:18]3[C:14]([C:10]4[CH:11]=[CH:12][CH:13]=[C:8]([NH:7][C:5]([NH:4][CH2:3][C:2]([F:33])([F:1])[F:34])=[O:6])[CH:9]=4)=[CH:15][N:16]=[C:17]3[CH:22]=2)[CH:24]=[N:25]1)[CH3:32]

参加物

3

反応物 2

HCID 69919504-(Methylamino)tetrahydro-2H-pyranHCID 679802202-(4-{3-[3-({[(2,2,2-trifluoroethyl)amino]carbonyl}amino)phenyl]imidazo[1,2-b]pyridazin-7-yl}-1H-pyrazol-1-yl)propanoic acid

生成物 1

HCID 57384890HCID 57384890、化合物

実験手順

This compound was prepared by using procedures analogous to those described for the synthesis of Example 54, Step 3 starting from 2-(4-{3-[3-({[(2,2,2-trifluoroethyl)amino]carbonyl}amino)phenyl]imidazo[1,2-b]pyridazin-7-yl}-1H-pyrazol-1-yl)propanoic acid and N-methyltetrahydro-2H-pyran-4-amine (Peakdale and Cat. No. 2006971). LCMS (M+H)+: m/z=571.3.

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-252ad9e2c5514c2c86e34fb15dd32bba
出典データセット
uspto-grants-2014_06
特許番号
US08754114B2

関連ノート

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