5-Methyl-1,2-oxazole-4-sulfonyl chloride → HCID 57385638、化合物

HRID 407051

反応式

HRID 407051 の反応式
[C:1]([CH2:3][C:4]1([N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[N:17][N:16]4[C:19]([C:22]5[CH:23]=[C:24]([NH:28][C:29]([NH:31][CH2:32][C:33]([F:36])([F:35])[F:34])=[O:30])[CH:25]=[CH:26][CH:27]=5)=[CH:20][N:21]=[C:15]4[CH:14]=3)[CH:10]=[N:9]2)[CH2:7][NH:6][CH2:5]1)#[N:2].[CH3:37][C:38]1[O:42][N:41]=[CH:40][C:39]=1[S:43](Cl)(=[O:45])=[O:44]>>[C:1]([CH2:3][C:4]1([N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[N:17][N:16]4[C:19]([C:22]5[CH:23]=[C:24]([NH:28][C:29]([NH:31][CH2:32][C:33]([F:35])([F:36])[F:34])=[O:30])[CH:25]=[CH:26][CH:27]=5)=[CH:20][N:21]=[C:15]4[CH:14]=3)[CH:10]=[N:9]2)[CH2:5][N:6]([S:43]([C:39]2[CH:40]=[N:41][O:42][C:38]=2[CH3:37])(=[O:45])=[O:44])[CH2:7]1)#[N:2]

参加物

3

反応物 2

HCID 27761415-Methyl-1,2-oxazole-4-sulfonyl chlorideHCID 67980375N-[3-(7-{1-[3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl]imidazo[1,2-b]pyridazin-3-yl)phenyl]-N'-(2,2,2-trifluoroethyl)urea

生成物 1

HCID 57385638HCID 57385638、化合物

実験手順

This compound was prepared by using procedures analogous to those described for the synthesis of Example 73, Step 4 starting from N-[3-(7-{1-[3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N′-(2,2,2-trifluoroethyl)urea and 5-methylisoxazole-4-sulfonyl chloride. LCMS (M+H)+: m/z=641.2.

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-a99a88ef4f21485a870712dc1199910e
出典データセット
uspto-grants-2014_06
特許番号
US08754114B2

関連ノート

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