Dimethylformamide dimethyl acetal → HCID 67278716、化合物
反応式
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([F:16])=[C:8]([N:10]([CH3:15])[S:11]([CH3:14])(=[O:13])=[O:12])[CH:9]=1)(=[O:3])[CH3:2].CO[CH:19](OC)[N:20]([CH3:22])[CH3:21]>CCCCCC>[CH3:19][N:20]([CH3:22])[CH:21]=[CH:2][C:1]([C:4]1[CH:5]=[CH:6][C:7]([F:16])=[C:8]([N:10]([CH3:15])[S:11]([CH3:14])(=[O:13])=[O:12])[CH:9]=1)=[O:3]参加物
4
実験手順
1.66 g (6.77 mmol) of N-(5-acetyl-2-fluoro-phenyl)-N-methyl-methanesulfonamide were dissolved in 3.35 ml (3.0 g) (25.18 mmol) of N,N-dimethylformamide dimethylacetal and the resultant solution was refluxed for 2.5 hours. The mixture was cooled at room temperature. To the solid formed was added 20 ml of n-hexane and filtered to yield a solid which was crystallized from ethyl acetate. 1.37 g of N-[5-(3-dimethylamino-acryloyl)-2-fluoro-phenyl]-N-methyl-methanesulfonamide as a yellowish-white solid were obtained (yield 67.4%).