Hydrochloric Acid → [1,3]Thiazolo[5,4-b]pyridin-2-amine

HRID 407283ノート

反応式

HRID 407283 の反応式
Cl[C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[S-:9][C:10]#[N:11].[NH4+].Cl>C(O)C>[N:8]1[C:7]2[C:2](=[N:3][CH:4]=[CH:5][CH:6]=2)[S:9][C:10]=1[NH2:11]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 15666Ammonium thiocyanateHCID 805282-Chloro-3-pyridylamine

生成物 1

HCID 592050[1,3]Thiazolo[5,4-b]pyridin-2-amine収率 43.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
85 °C

実験手順

A suspension of 2-chloro-3-aminopyridine (3 g, 23 mmole), and ammonium thiocyanate (3.5 g, 46.5 mmole) in 23 mL of ethanol was acidified with conc. HCl to pH ˜1 (˜1.8 mL). The reaction mixture was heated to 85° C. for 3 days. At this point, the solvent was evaporated and residual water was removed aziotropically by the distillation of 2-propanol. The yellow residue was mixed with 12 mL of 7 M ammonium hydroxide and 7 mL of chloroform. The solid was isolated by filtration to yield 1.50 g (43%) of the product as a white powder. MS (m/z, ES+): 152 (M+1, 100%).

後処理

  1. customAt this point, the solvent was evaporated
  2. customresidual water was removed aziotropically by the distillation of 2-propanol
  3. additionThe yellow residue was mixed with 12 mL of 7 M ammonium hydroxide and 7 mL of chloroform
  4. customThe solid was isolated by filtration

出典と根拠

ORDレコード
ord-73ae2f84383247c7887d5a6d645f6adf
出典データセット
uspto-grants-2014_06
特許番号
US08754233B2

反応ノート

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