関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 3-Cyclopropyl-3-oxopropanenitrile | HCID 9812763 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | HCID 178507266 | HCID 178507266 | 46% |
反応手順
To a solution of 126a (477 mg, 4.38 mmol) in methanol (5 mL) was added hydrazine hydrate (5 mL, 80%). The reaction mixture was heated at 75° C. for 15 h. The methanol was removed under reduced pressure and the residue was extracted with dichloromethane (2×8 mL). The combined extract was dried over Na2SO4 and concentrated. The residue was purified by flash column eluting with 100:1 dichloromethane/methanol to afford 126b as a yellow oil (250 mg, 46%, over two steps). MS: [M+H]+ 124.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08754077B2 |
|---|
| 出典データセット | uspto-grants-2014_06 |
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| ORD ID | ord-88610df068c5463ebeb89141e5da1e97 |
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| 出典メモ | uspto-grants-2014_06 |
|---|
