Ethanol → Ethyl 3-nitropropionic acid

HRID 408446ノート

反応式

HRID 408446 の反応式
[N+:1]([CH2:4][CH2:5][C:6]([OH:8])=[O:7])([O-:3])=[O:2].S(=O)(=O)(O)O.[CH2:14](O)[CH3:15]>>[CH2:14]([CH:5]([CH2:4][N+:1]([O-:3])=[O:2])[C:6]([OH:8])=[O:7])[CH3:15]

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 16783-Nitropropionic acid

生成物 1

HCID 86703358Ethyl 3-nitropropionic acid

実験手順

To a solution of 2 gr of 3-nitropropionic acid (41) in 30 mL of ethanol add catalytic amount of concentrated sulphuric acid (0.8 mL) and reflux overnight. Then add water and extracted with ethylacetate. The organic layer was washed with saturated sodium bicarbonate solution, saturated sodium chloride and water. Purification from column gives ethyl 3-nitropropionic acid (26) as pale yellow liquid with boiling point 92° C. at 2.5 torr.

後処理

  1. temperaturereflux overnight
  2. extractionThen add water and extracted with ethylacetate
  3. washThe organic layer was washed with saturated sodium bicarbonate solution, saturated sodium chloride and water
  4. customPurification from column

出典と根拠

ORDレコード
ord-5550a87ede2a43dfb5d94e8070cc45ac
出典データセット
uspto-grants-2014_06
特許番号
US08759339B2

反応ノート

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