Sodium Chloride → 2-(2-Methoxyphenyl)acetaldehyde

HRID 408492

反応式

HRID 408492 の反応式
S(=O)(=O)=O.[CH3:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][CH2:14][OH:15].C(N(CC)CC)C.[Cl-].[Na+]>CS(C)=O.ClCCl>[CH3:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][CH:14]=[O:15]

参加物

7

反応物 4

HCID 5234Sodium ChlorideHCID 8471TriethylamineHCID 24682Sulfur trioxideHCID 819092-Methoxyphenethyl alcohol

生成物 1

HCID 2695482-(2-Methoxyphenyl)acetaldehyde収率 86%

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 6344Dichloromethane溶媒

実験手順

A solution of pyridine complex with sulfur trioxide (134 g, 0.842 mol) in dimethylsulfoxide (150 mL) was slowly added to a solution of 2-(2-methoxy-phenyl)-ethanol (43 g, 0.28 mol) and triethylamine (86 g, 0.85 mol) in dichloromethane (500 mL) at 0° C. After being stirred 30 min, the mixture was poured into a saturated aqueous solution of sodium chloride and the organic layer was washed with dilute hydrochloric acid, a saturated aqueous solution of sodium chloride, dried over sodium sulfate and evaporated to dryness to give (2-methoxy-phenyl)-acetaldehyde (36 g, 0.24 mol, 86%) which was used in the next step directly.

後処理

  1. washthe organic layer was washed with dilute hydrochloric acid
  2. dry with materiala saturated aqueous solution of sodium chloride, dried over sodium sulfate
  3. customevaporated to dryness

出典と根拠

ORDレコード
ord-74a84c87c09243949b11f5548591bc27
出典データセット
uspto-grants-2014_06
特許番号
US08759335B2

関連ノート

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