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1,2,3,4-Tetrahydroquinoline → 1-(4-Bromo-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
| 反応物 | 4-Bromo-1-fluoro-2-nitrobenzene | HCID 2736328 | — |
| 反応物 | N-[2-(2,3-dihydro-1H-indol-1-yl)-5-fluorophenyl]-4-methyl-1-piperazine carboxamide maleate | HCID 70406853 | — |
| 生成物 | 1-(4-Bromo-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline | HCID 13812927 | — |
| 生成物 | 5-Bromo-2-[3,4-dihydro-1(2H)-quinolinyl]aniline | HCID 13812931 | — |
| 生成物 | 10-bromo-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine | HCID 13812943 | — |
反応手順
Starting with 1,2,3,4-tetrahydroquinoline and 5-bromo-2-fluoronitrobenzene and following the steps of 1a to 1f of Example 2, one may obtain, in sequence, 1-(4-bromo-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline, 1-(2-amino-4-bromophenyl)-1,2,3,4-tetrahydroquinoline, N-[2-{1-(5-bromophenyl)-1,2,3,4-tetrahydroquinolin-1-yl}]-4-methyl-1-piperazine carboxamide, and 10-bromo-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04723003 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-f25e2397d0e44ac98f1fbbc579c59523 |
| 出典メモ | uspto-grants-1988_02 |