化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 1-(4-Methoxy-phenyl)-cyclopropanecarboxylic acid benzothiazol-2-ylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzo(d)thiazol-2-amine | HCID 8706 | — |
| 反応物 | 1-(4-Methoxyphenyl)cyclopropane-1-carboxylic acid | HCID 85575 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(4-Methoxy-phenyl)-cyclopropanecarboxylic acid benzothiazol-2-ylamide | HCID 11551566 | 26% |
反応手順
Benzothiazol-2-ylamine (30. mg, 0.20 mmol) and 1-(4-methoxy-phenyl)-cyclopropanecarboxylic acid (38 mg, 0.20 mmol) were dissolved in N,N-dimethylformamide (DMF, 1 mL) containing triethylamine (84 μL, 0.60 mmol). O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU, 80 mg, 0.21 mmol) was added and the solution was allowed to stir at room temperature for 16 hours. The crude product was purified by reverse-phase preparative liquid chromatography to yield the pure product (17 mg, 0.052 mmol, 26%). ESI-MS m/z calc. 324.1. found 325.0 (M+1)+. Retention time of 3.48 minutes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08759335B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-c42464d75a4a4067a58a95e9a07da791 |
| 出典メモ | uspto-grants-2014_06 |