化工社化工社 化学情報印刷レポート · 研究参考用
Thionyl Chloride → 2-(Chloromethyl)-1-benzothiophene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2-(Hydroxymethyl)benzo[b]thiophene | HCID 2776335 | — |
| 生成物 | 2-(Chloromethyl)-1-benzothiophene | HCID 12813837 | — |
反応手順
A solution of benzo[b]thiophen-2-yl-methanol (1 eq.) in thionyl chloride was stirred at 20° C. for 1 h. The crude was concentrated under reduced pressure then partitioned between a saturated aqueous solution of NaHCO3 and EtOAc. The organic layer was separated, dried over MgSO4, filtered and concentrated under reduced pressure to afford 2-chloromethyl-benzo[b]thiophene, used as such without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08759334B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-3af8ca641c4b4f908efe1476df255b10 |
| 出典メモ | uspto-grants-2014_06 |