Hydrochloric Acid → 4-Chloroquinolin-6-amine
反応式
O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH:12]C(=O)C)[CH:10]=2)[N:5]=[C:4](C)[CH:3]=1.[ClH:17]>CO>[NH2:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][CH:3]=[C:2]2[Cl:17]参加物
4
実験手順
N-(4-Hydroxy-2-methylquinolin-6-yl)acetamide (0.05 g; see step (i) above), methanol (2 mL) and 5 N hydrochloric acid (6 mL) was refluxed for 90 minutes. The reaction mixture was evaporated and the residue dissolved in ethyl acetate and sodium carbonate solution. The organic phase was washed with water, dried (Na2SO4), filtered and concentrated to give the sub-title compound as a pale yellow solid.
後処理
- customThe reaction mixture was evaporated
- dissolutionthe residue dissolved in ethyl acetate
- washThe organic phase was washed with water
- dry with materialdried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-97ecbca0bc5e4d15a2208d4749715aff
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08759348B2
反応ノート
読み込み中…