Hydrochloric Acid → Methyl 2-(4-hydroxyphenoxy)acetate

HRID 408671

反応式

HRID 408671 の反応式
C([O:4][C:5]1[CH:16]=[CH:15][C:8]([O:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[CH:7][CH:6]=1)(=O)C.C[O-].[Na+].Cl>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[CH:15][CH:16]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 20717764Methyl (4-acetoxy-phenoxy)-acetate

生成物 1

HCID 602731Methyl 2-(4-hydroxyphenoxy)acetate収率 85%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a 100 ml round flask were added 1.512 g methyl (4-acetoxy-phenoxy)-acetate dissolved in 50 ml anhydrous methanol, 0.364 g sodium methoxide. The mixture was stirred at room temperature for 1 hour. To the stirred mixture was added dilute HCl to adjust pH to weak acidity. The solvent was removed by evaporation. To the residue was added water. The solution was extracted with ethyl acetate for three times. The extract was dried, filtrated and evaporated to obtain 1.004 g of a brown solid, yield 85%. 1H-NMR (400 MHz, DMSO-d6, δ ppm) δ 3.679 (3H, s), 4.646 (2H, s), 6.672 (2H, d), 6.754 (2H, d), 9.0 (1H, s).

後処理

  1. customThe solvent was removed by evaporation
  2. additionTo the residue was added water
  3. extractionThe solution was extracted with ethyl acetate for three times
  4. customThe extract was dried
  5. filtrationfiltrated
  6. customevaporated

出典と根拠

ORDレコード
ord-c36ed3d2892942d79344c5d41152f084
出典データセット
uspto-grants-2014_06
特許番号
US08759355B2

関連ノート

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